Acute Intestinal Failure


Professor Oivind IRTUN, MD, PhD, MPH 
Department of Gastroenterological Surgery
University Hospital North-Norway
AIF Group Members: 
Ass. professor Mihailo BEZMAREVIC, MD, PhD
General Surgeon
Clinic for General Surgery, Military Medical Academy
Bose Milicevic 4, 11000 Belgrade, Serbia
Phone: +381641994288
Intensivist, Researcher/Scientist
Intensive Care Unit                  -    Department of Anaesthesiology and Intensive Care
Lucerne Cantonal Hospital      -    University of Tartu
Spitalstrasse                             -     Puusepa 8
6000 LUCERNE                     -    51014 TARTU
Switzerland                             -    Estonia
Nutritional Support Unit Coordinator
University Hospital Vall d'Hebron
Vall d’Hebron Barcelona Hospital Campus
Pg Vall d'Hebron 119-129
Professor Alastair FORBES BSc MB MD(Res) FRCP FRCPE FHEA
Külalis Professor of Medicine
Institute of Clinical Medicine, University of Tartu,
Puusepa, 51014, Tartu, Estonia
and Emeritus Professor of Medicine
University of East Anglia, Norwich, UK
Dr. Simon GABE, MD, MSc, MBBS, BSc, FRCP      
Consultant in Gastroenterology & Intestinal Rehabilitation
Honorary Senior Lecturer, Imperial College
Co-chair of the Lennard-Jones Intestinal Failure Unit, St Mark's
St Mark's Hospital
Watford Road
United Kingdom
Professor Mette HOLST, PhD
Aalborg University Hospital
Centre for Nutrition and Intestinal Failure
Department of Gastroenterology
Aalborg University Hospital and Department of Clinical Medicine, Aalborg University
Danish Nutrition Science Centre
Professor Stanislaw KLEK, MD, PhD
Surgical Oncology Unit
The Maria Sklodowska-Curie National Research Institute of Oncology
11 Garncarska Street, 31-115 Krakow
Professor Loris PIRONI, MD,
Center for Chronic Intestinal Failure,
St. Orsola University Hospital
Via Massarenti, 9

Professor Henrik Højgaard RASMUSSEN, MD, PhD,
Chief Physician Centre for Nutrition and Intestinal Failure (CET) & Danish Nutrition Science Centre (DANSC)
Department of Gastroenterology and Hepatology
Clinical Institute, Aalborg University Hospital and Aalborg University
Mølleparkvej 4, DK-9000 Aalborg, Denmark
Professor at Dietetic and Nutritional Research Unit,
Herlev Gentofte Hospital, Herlev, Denmark
Professor Mireille SERLIE, MD, PhD,
Director TPN & Intestinal Failure Clinic Amsterdam University Medical Center
Chairperson of NESPEN (Dutch Society of Clinical Nutrition and Metabolism)
Department of Endocrinology and Metabolism
Amsterdam University Medical Center, location AMC
Meibergdreef 9 (K2-283)
1105 AZ Amsterdam
The Netherlands
Professor Mattias SOOP, MD, PhD,
Head of Department
Karolinska Comprehensive Cancer Center
Department for Inflammatory Bowel Disease and Intestinal Failure Surgery
Karolinska University Hospital,
Stockholm, Sweden
+46 70 286 5243| 
Professor Ronan THIBAULT, MD, PhD,
Head of Nutrition Unit, HPN Centre
Rennes University Hospital (CHU Rennes) – University of Rennes
NuMeCan (Nutrition Metabolism Cancer) Institute, INSERM, INRAE, Univ Rennes,            2 rue Henri Le Guilloux
35000  RENNES
Current ongoing activity:

A worldwide survey to assess the management of patients with mesenteric ischaemia & infarction:

Patients with mesenteric ischaemia often have a significant delay until a diagnosis is made and some then present with a mesenteric infarction. There may be differences in the availability of appropriate investigations and treatments as well as differences in teaching and awareness in different settings. We wish to assess the importance of some of these factors prior to conducting a more formal observational study.
We are conducting a survey to assess the different approaches to the management of patients with mesenteric ischaemia and intestinal infarction and kindly invite clinicians to participate. 
SIG (Acute Intestinal Failure).

Started: August 2010 (at 33rd ESPEN Congress in Nice)

Field of interest: Nutritional and metabolic disorders in acute intestinal failure (AIF) and the compromised gut (CG)
Aims: To perform scientific and epidemiological studies in the field of AIF and the conditions that lead to AIF.
To provide guidelines for both of these topics.
To participate in the education of professionals with an interest in AIF and CG.

Composition of the group: The ESPEN-AIF Special Interest Group has a maximum of 12 members. 
The group is multidisciplinary and members are recruited from physicians, pharmacists, nurses and dieticians. Membership of the group is normally limited to 4 years, but can be extended to assure continuity if the member vigorously participates in the SIG AIF’s activities.  

Presentation of the work of AIF Group: The coordinator of the study, paper or guidelines is normally the first author of the publication. The rest of authors are included in the authors list based on the contribution to the study.
Others, who contributed to the study, are mentioned in the "acknowledgements" section. 
Papers are submitted to the ESPEN meetings and manuscripts to one of the ESPEN journals or other relevant journals.

Meetings of the AIF group: The group convenes for at least two meetings every year. The Winter meeting is held during a week-end in January in a city selected by members.
The second meeting takes place during the ESPEN meeting in August or September.
An open meeting is organized during the ESPEN congress in order to give delegates the opportunity to learn about the activities of the group and recruit new members The information on the web site is adjusted at half-year intervals or when appropriate.

Members must fulfill the following criteria: 
Members of ESPEN.
Enthusiasm for and affinity with the work of the group.  
Expertise in the field of AIF and/or CG. 
Members must be approved by their national society for clinical nutrition 
A list of the members of the AIF SIG will be submitted to ESPEN Executive committee each year

Financial support:
ESPEN provides financial support. The budget has to be accepted by the ESPEN Executive committee. All expenses must be clearly defined (meetings, secretariat, mailing etc.).
Members of AIF group are encouraged to generate financial support from pharmaceutical companies or other sources. The ESPEN treasurer will control any money raised.

The group has contributed to the ESPEN LLL program at the Barcelona congress, 2012:  
1. Nutritional Support in Gastrointestinal Disease
Chairman: Jon Shaffer
Lecturers: Jon Shaffer, Remy Meier, Steven Olde Damink, Stanislaw Klek
 2. Educational session - High output fistulae management – case discussion
Moderators: Jon Shaffer, Alistair Forbes 
Case presentation: Oivind Irtun 
Experts: Marek Pertkiewicz, Steven Olde Damink, Geert Wanten, Henrik Rasmussen
Outside experts: A. Weimann, P. Soeters   Z. Krznaric
The group has contributed to the ESPEN LLL program at Leipzig congress, 2013:  
1. Nutritional Support in Gastrointestinal Disease
Topic 12: ‘Nutritional Support in Gastrointestinal Disease’
Chairman: Jon Shaffer
Lecturers: Jon Shaffer, Remy Meier, Stanislaw Klek 
ESPEN congress Lisbon, 2015:
The group has contributed to til Case discussion - Intestinal obstruction by malignancy
Case presentation: Surgical treatment of malignant bowel obstruction, R. Burgos
Panelists: Ø. Irtun, M. Holst, S. Klek, N. Wierdsma, A. Neves
ESPEN congress Madrid, 2018:
Case discussion: Critically ill septic patient with multiorgan failure.
Case presenter: Annika Reintam Blaser
Panelists: C. Vaquerizo, M. Pietka, M. van de Poll, M. Holst, R. Thibault, R. Burgos, D. Lobo

Acute intestinal failure: International multicenter point-of-prevalence study.
Reintam Blaser A, Ploegmakers I, Benoit M, Holst M, Rasmussen HH, Burgos R, Forbes A, Shaffer J, Gabe S, Irtun O, Thibault R, Klek S, Olde Damink SW, van de Poll M, Panisic-Sekeljic M, Wanten G, Pironi L; AIF study group. Clin Nutr. 2020 Jan;39(1):151-158. doi: 10.1016/j.clnu.2019.01.005. Epub 2019 Jan 15. PMID: 30683610.
Intestinal failure in adults: Recommendations from the ESPEN expert groups.  Pironi L, Corcos O, Forbes A, Holst M, Joly F, Jonkers C, Klek S, Lal S, Reintam Blaser A, Rollins KE, Sasdelli AS, Shaffer J, Van Gossum A, Wanten G, Zanfi C, Lobo DN; ESPEN Acute and Chronic Intestinal Failure Special Interest Groups.  Clin Nutr. 2018 Dec;37(6 Pt A):1798-1809. doi: 10.1016/j.clnu.2018.07.036. Epub 2018 Aug 18.

Management of acute intestinal failure: A position paper from the European Society for Clinical Nutrition and Metabolism (ESPEN) Special Interest Group
tanislaw Klek, Alastair Forbes, Simon Gabe, Mette Holst, Geert Wanten, Øivind Irtun, Steven Olde Damink, Marina Panisic-Sekeljic, Rosa Burgos Pelaez, Loris Pironi, Annika Reintam Blaser, Henrik Højgaard Rasmussen, Stéphane M Schneider, Ronan Thibault, Ruben G J Visschers, Jonathan Shaffer. Clin Nutr. 2016 Dec;35(6):1209-1218. doi: 10.1016/j.clnu.2016.04.009. Epub 2016 Apr 19.

ESPEN endorsed recommendations. Definition and classification of intestinal failure in adults. 
Pironi L, Arends J, Baxter J, Bozzetti F, Peláez RB, Cuerda C, Forbes A, Gabe S, Gillanders L, Holst M, Jeppesen PB, Joly F, Kelly D, Klek S, Irtun Ø, Olde Damink SW, Panisic M, Rasmussen HH, Staun M, Szczepanek K, Van Gossum A, Wanten G, Schneider SM, Shaffer J; Home Artificial Nutrition & Chronic Intestinal Failure; Acute Intestinal Failure Special Interest Groups of ESPEN. Clin Nutr. 2015 Apr;34(2):171-80. doi: 10.1016/j.clnu.2014.08.017. Epub 2014 Sep 21.
The management of patients with high output enterocutaneous gastrointestinal fistulae: a European Survey.
Gabe SM, Shaffer JL, Forbes A, Holst M, Irtun O, Klek S, Damink SO, Pertkiewicz M, Pironi L, Rasmussen HH, van Gemert WG, Wanten G. Clin Nutr. 2012: Suppl 1:14-15